Formulation and Evaluation of Gastroretentive Drug Delivery System of Acyclovir as Mucoadhesive Nanoparticles
نویسندگان
چکیده
The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formulation F4 with 1:2 gelatin and Pluronic F-68 in 1:2 showed satisfactory results i.e. average particle size 207.7 nm, polydispersity index 0.338, entrapment efficiency 54.21%, loading efficiency 43.13% and mucoadhesive strength of 6.012 g. FTIR study concluded that there was no major interaction occurred between the drug and polymers used in the present study.
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Formulation and In Vitro Evaluation of Acyclovir Mucoadhesive Microspheres for Intravaginal Application
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