Formulation and Evaluation of Gastroretentive Drug Delivery System of Acyclovir as Mucoadhesive Nanoparticles

نویسندگان

  • Ankit Anand Kharia
  • Akhlesh Kumar Singhai
چکیده

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. Nanoparticulate formulation F4 with 1:2 gelatin and Pluronic F-68 in 1:2 showed satisfactory results i.e. average particle size 207.7 nm, polydispersity index 0.338, entrapment efficiency 54.21%, loading efficiency 43.13% and mucoadhesive strength of 6.012 g. FTIR study concluded that there was no major interaction occurred between the drug and polymers used in the present study.

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تاریخ انتشار 2013